Hematologic malignancies (leukemias and lymphomas) can emerge at any point of the hematopoiesis cascade's differentiation. While visual examination under the microscope can occasionally provide insight into the type of hematologic malignancy, the morphologic appearance is not always adequate to subcategorize the cancer. Hematological malignancies, which include leukaemia, lymphoma, and plasma cell dyscrasia, are malignancies of the blood and blood-forming organs (bone marrow and lymphoid tissues). Every year, millions of adults and children are diagnosed with haematological malignancies such as leukaemia and lymphoma, which are often fatal. Bone marrow transplantation is a well-established treatment for many disorders, with defective blood progenitor cells being replaced with healthy stem cells to achieve cure. Tumors of the hematopoietic and lymphoid tissues and tumours of the haematopoietic and lymphoid tissues affect the blood, bone marrow, lymph, and lymphatic system. Because these tissues are all linked by the circulatory and immunological systems, a sickness that affects one will typically impact the others as well, making myeloproliferation and lymphoproliferation (and consequently leukemias and lymphomas) closely related and frequently overlapping conditions.